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汪汪队立大功!科学家发现人犬通用“肥胖基因”

肥胖已成为全球性的健康挑战,其复杂的遗传机制尚未完全阐明。近日,一项发表于《科学》杂志的研究通过对拉布拉多犬进行全基因组关联分析(GWAS),成功识别出一个与人犬共同的肥胖相关关键基因——DENND1B

研究表明,该基因的特定变异与犬类体脂增加显著相关,每个等位基因拷贝可导致体脂增加约7% 。进一步的跨物种研究证实,DENND1B 基因同样在人类肥胖中扮演重要角色,它通过调节黑皮质素4受体(MC4R)的信号传导与转运,参与能量平衡的精细调控过程 。

此项研究不仅揭示了犬类与人类肥胖的共同遗传基础,也突显了犬类作为研究复杂人类疾病模型的独特优势 。这一发现为深入理解肥胖的病理生理机制提供了新线索,并可能为未来开发针对人和犬的肥胖干预策略开辟新途径。

原来我和我家狗子一起月半,是有科学依据的!


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汪汪队立大功!科学家发现人犬通用“肥胖基因”

肥胖已成为全球性的健康挑战,其复杂的遗传机制尚未完全阐明。近日,一项发表于《科学》杂志的研究通过对拉布拉多犬进行全基因组关联分析(GWAS),成功识别出一个与人犬共同的肥胖相关关键基因——DENND1B

研究表明,该基因的特定变异与犬类体脂增加显著相关,每个等位基因拷贝可导致体脂增加约7% 。进一步的跨物种研究证实,DENND1B 基因同样在人类肥胖中扮演重要角色,它通过调节黑皮质素4受体(MC4R)的信号传导与转运,参与能量平衡的精细调控过程 。

此项研究不仅揭示了犬类与人类肥胖的共同遗传基础,也突显了犬类作为研究复杂人类疾病模型的独特优势 。这一发现为深入理解肥胖的病理生理机制提供了新线索,并可能为未来开发针对人和犬的肥胖干预策略开辟新途径。

原来我和我家狗子一起月半,是有科学依据的!


Science

via Ziyu|好想躺平🦆

📮投稿 ☘️频道 🧧狗东

BY 科技圈🎗在花频道📮






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