Обложка иллюстрирует реконструктивную стратегию региоспецифического синтеза новых ациклических аналогов пуриновых нуклеозидов. Эта методология вдохновлена жизненным циклом бабочки, который начинается с яйца (аминогуанидин), превращающегося в гусеницу (5-аминотетразол), которая формирует куколку (6-нитро-7-алкиламинотетразоло[1,5-a]пиримидины). Последняя служит основой для превращения в прекрасную бабочку (желаемые аналоги пуриновых нуклеозидов, включая аналог пенцикловира), которая вырывается из своей оболочки (деструктивное восстановление тетразольного цикла вместе с нитрогруппой), чтобы расправить крылья.
Обложка иллюстрирует реконструктивную стратегию региоспецифического синтеза новых ациклических аналогов пуриновых нуклеозидов. Эта методология вдохновлена жизненным циклом бабочки, который начинается с яйца (аминогуанидин), превращающегося в гусеницу (5-аминотетразол), которая формирует куколку (6-нитро-7-алкиламинотетразоло[1,5-a]пиримидины). Последняя служит основой для превращения в прекрасную бабочку (желаемые аналоги пуриновых нуклеозидов, включая аналог пенцикловира), которая вырывается из своей оболочки (деструктивное восстановление тетразольного цикла вместе с нитрогруппой), чтобы расправить крылья.
Unlike Silicon Valley giants such as Facebook and Twitter, which run very public anti-disinformation programs, Brooking said: "Telegram is famously lax or absent in its content moderation policy." Channels are not fully encrypted, end-to-end. All communications on a Telegram channel can be seen by anyone on the channel and are also visible to Telegram. Telegram may be asked by a government to hand over the communications from a channel. Telegram has a history of standing up to Russian government requests for data, but how comfortable you are relying on that history to predict future behavior is up to you. Because Telegram has this data, it may also be stolen by hackers or leaked by an internal employee. Telegram has gained a reputation as the “secure” communications app in the post-Soviet states, but whenever you make choices about your digital security, it’s important to start by asking yourself, “What exactly am I securing? And who am I securing it from?” These questions should inform your decisions about whether you are using the right tool or platform for your digital security needs. Telegram is certainly not the most secure messaging app on the market right now. Its security model requires users to place a great deal of trust in Telegram’s ability to protect user data. For some users, this may be good enough for now. For others, it may be wiser to move to a different platform for certain kinds of high-risk communications. Soloviev also promoted the channel in a post he shared on his own Telegram, which has 580,000 followers. The post recommended his viewers subscribe to "War on Fakes" in a time of fake news. Apparently upbeat developments in Russia's discussions with Ukraine helped at least temporarily send investors back into risk assets. Russian President Vladimir Putin said during a meeting with his Belarusian counterpart Alexander Lukashenko that there were "certain positive developments" occurring in the talks with Ukraine, according to a transcript of their meeting. Putin added that discussions were happening "almost on a daily basis."
from sg
