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人体肺活量衰减始于 20-25 岁

2025-05-20 14:44 by 时间的地图

一项研究首次揭示了肺活量从童年到老年的演变过程。学术界此前认为,人体肺功能在20至25岁达到顶峰,之后趋于稳定,并于成年后期随着肺部衰老而开始衰退。然而,这一模型是基于并未覆盖全生命周期的研究建立的。相比之下,新研究采用了“加速队列设计”,即将多项队列研究数据整合以覆盖所需年龄范围。研究显示,肺功能存在两个发展阶段——童年期的快速增长阶段,以及延续至肺功能峰值前的缓慢增长阶段。研究使用两个参数评估肺功能:第一秒用力呼气容积(FEV1)——深吸气后第一秒呼出的气体量,以及用力肺活量(FVC)——深吸气后无时间限制的最大呼气量。女性在20岁左右FEV1达到峰值,男性则在23岁左右。出人意料的是,研究发现,峰值后并不存在稳定期。分析表明,持续性哮喘和吸烟都会影响肺功能,但方式与既往认知不同。持续性哮喘患者会更早达到FEV1峰值且终生处于较低水平,而吸烟者从35岁开始出现更快的肺功能下降。

doi.org/10.1016/S2213-2600(25)00043-8
中国科学报:肺活量衰减始于20至25岁

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人体肺活量衰减始于 20-25 岁

2025-05-20 14:44 by 时间的地图

一项研究首次揭示了肺活量从童年到老年的演变过程。学术界此前认为,人体肺功能在20至25岁达到顶峰,之后趋于稳定,并于成年后期随着肺部衰老而开始衰退。然而,这一模型是基于并未覆盖全生命周期的研究建立的。相比之下,新研究采用了“加速队列设计”,即将多项队列研究数据整合以覆盖所需年龄范围。研究显示,肺功能存在两个发展阶段——童年期的快速增长阶段,以及延续至肺功能峰值前的缓慢增长阶段。研究使用两个参数评估肺功能:第一秒用力呼气容积(FEV1)——深吸气后第一秒呼出的气体量,以及用力肺活量(FVC)——深吸气后无时间限制的最大呼气量。女性在20岁左右FEV1达到峰值,男性则在23岁左右。出人意料的是,研究发现,峰值后并不存在稳定期。分析表明,持续性哮喘和吸烟都会影响肺功能,但方式与既往认知不同。持续性哮喘患者会更早达到FEV1峰值且终生处于较低水平,而吸烟者从35岁开始出现更快的肺功能下降。

doi.org/10.1016/S2213-2600(25)00043-8
中国科学报:肺活量衰减始于20至25岁

#科学

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To that end, when files are actively downloading, a new icon now appears in the Search bar that users can tap to view and manage downloads, pause and resume all downloads or just individual items, and select one to increase its priority or view it in a chat. Oleksandra Matviichuk, a Kyiv-based lawyer and head of the Center for Civil Liberties, called Durov’s position "very weak," and urged concrete improvements. In February 2014, the Ukrainian people ousted pro-Russian president Viktor Yanukovych, prompting Russia to invade and annex the Crimean peninsula. By the start of April, Pavel Durov had given his notice, with TechCrunch saying at the time that the CEO had resisted pressure to suppress pages criticizing the Russian government. He adds: "Telegram has become my primary news source." The next bit isn’t clear, but Durov reportedly claimed that his resignation, dated March 21st, was an April Fools’ prank. TechCrunch implies that it was a matter of principle, but it’s hard to be clear on the wheres, whos and whys. Similarly, on April 17th, the Moscow Times quoted Durov as saying that he quit the company after being pressured to reveal account details about Ukrainians protesting the then-president Viktor Yanukovych.
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